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Nikon
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Image Search Results
Journal: Journal of Translational Medicine
Article Title: Silencing PinX1 enhances radiosensitivity and antitumor-immunity of radiotherapy in non-small cell lung cancer
doi: 10.1186/s12967-024-05023-y
Figure Lengend Snippet: Silencing PinX1 combined with IR increased CD8 + T cell recruitment. A Lewis cells were transfected with a control or shPinX1 lentivirus and analyzed by western blotting. B. Experimental schedule of varied treatment regimens for LLC tumor-bearing mice. C Representative photos of tumor xenografts 14 days after the initiation of IR. D Tumor volume of xenografts was shown in the graphs. Two-way ANOVA with Tukey’s multiple comparison test was conducted for tumor volume analysis with GraphPad Prism 8.0.2. n = 5 mice/group. E Survival data were compared using log-rank Mantel-Cox test. n = 8 mice/group. F – K Representative flow cytometry staining and frequencies of total CD8 + /CD3 + cells, PD-1 + Tim-3 + /CD8 + T cells, and Gzmb + /CD8 + T cells in tumors. n = 5 mice/group. Data are presented as the mean ± standard deviation, *: p < 0.05, **: p < 0.01, *** p : < 0.001, ****: p < 0.0001
Article Snippet: Two-way ANOVA with Tukey’s multiple comparison was conducted for tumor volume analysis with
Techniques: Transfection, Western Blot, Comparison, Flow Cytometry, Staining, Standard Deviation
Journal: Journal of Translational Medicine
Article Title: Silencing PinX1 enhances radiosensitivity and antitumor-immunity of radiotherapy in non-small cell lung cancer
doi: 10.1186/s12967-024-05023-y
Figure Lengend Snippet: Silencing PinX1 potentiates the antitumor efficacy of radioimmunotherapy. A Experimental schedule of varied treatment regimens for LLC tumor-bearing mice. B Representative photos of tumor xenografts 14 days after the initiation of IR. C Tumor volume of xenografts was shown in the graphs. Two-way ANOVA with Tukey’s multiple comparison was conducted for tumor volume analysis with GraphPad Prism 8.0.2. n = 5 mice/group. D , E Representative flow cytometry staining and frequencies of total CD8 + /CD3 + cells in tumors. n = 5 mice/group. F , G Representative flow cytometry staining and frequencies of PD-1 + Tim-3 + /CD8 + T cells in tumors. n = 5 mice/group. H – J . Representative flow cytometry staining and frequencies of CD86 + CD206 − /CD45 + F4/80 + CD11b + cells and CD86 − CD206 + /CD45 + F4/80 + CD11b + cells cells in tumors. n = 5 mice/group. Data are presented as the mean ± standard deviation. *: p < 0.05, **: p < 0.01, ***: p < 0.001, ****: p < 0.0001
Article Snippet: Two-way ANOVA with Tukey’s multiple comparison was conducted for tumor volume analysis with
Techniques: Comparison, Flow Cytometry, Staining, Standard Deviation